Nervous System: Michael Jacksons DeathThe first reports of Michael Jacksons death stated that he died of cardiac arrest. While this was true, it doesnt tell us what CAUSED his heart to stop.The autopsy discovered the Michaels heart was essentially normal, but what was abnormal were the drugs found in his blood. All of the drugs found in his blood were gamma-aminobutyric acid (GABA) agonists drugs that simulate and increase the normal effects of GABA on the brain. GABA is a neurotransmitter found only in the central nervous system. When GABA binds to receptors on the surface of nerve cells, it allows Cl- to flow into the cell. Michaels personal doctor was giving Michael these drugs, but this time accidentally gave him too much. Usually GABA agonists are given under close supervision with heart rate and respiratory rate monitors.1.) What effect does GABA have on the membrane potential of a nerve cell. Use observations about how Na+ and K+ affect the membrane potential when they flow in and out of a cell to make your conclusion.2.) Draw a graph (Time vs mV) of an action potential in a nerve cell with a normal membrane potential. Label the normal resting potential and draw in the threshold at the appropriate mV. Now draw the same graph showing the resting potential of a nerve cell with GABA bound to it and how the action potential would be different.?4.) Michael wanted his doctor to give him these drugs at night. Do you think Michael wanted to stay up all night, or go to sleep?? Use your observations in question 2 and 3 to support your answer.5.) Why are GABA agonists usually given with heart rate and respiratory rate monitors? Use your observations in questions 2 and 3, plus your knowledge of respiratory rate regulation to support your answer.6.) Why did Michaels heart stop? One observation: there is a cardioregulatory center in the medulla oblongata that is responsible for regulating heart rate.
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